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Five Causes and Solutions of Insufficient Compressive Hardness of Three-layer Tablet Press
Release time:
2020-08-20 12:04
Source:
three-layer tablet pressIn the process of operation, it is inevitable that the pressed tablets are not hard enough, which is a very distressing thing. Let's analyze the following causesthree-layer tablet pressThe reasons for the pressure is not hard and the solution. _Multifunctional Tablet Press_Catalyst Tablet Press_High Speed Tablet Press_Disinfectant Tablet Press_Tablet Press
(1)Reason: the amount of binder or lubricant is small or inappropriate, so that the particle distribution is uneven, coarse particles and fine particles stratification,three-layer tablet pressEven if the pressure is increased, it cannot be overcome.
Solution: can choose the appropriate adhesive or increase the amount, improve the granulation process, mixed particles and other methods. _Multifunctional Tablet Press_Catalyst Tablet Press_High Speed Tablet Press_Disinfectant Tablet Press_Tablet Press
(2)Reason: crushing fineness is not enough, rich fiber, elasticityParticlesOr oil content is more uneven mixing.
Solution: You canParticlesSmash finer, choose strong adhesive, increase.three-layer tablet pressThe pressure, refueling drug absorbent and fully mixed and other methods. _Multifunctional Tablet Press_Catalyst Tablet Press_High Speed Tablet Press_Disinfectant Tablet Press_Tablet Press
(3)Reason: water content is not moderate, too little water or dry particles elastic, due to the drug containing crystal water in the particle drying to lose more crystal water, brittle, easy to crack. But too much hardness becomes small.
Solution: the granulation process should be controlled according to different varieties of water content. If the granules are too dry, an appropriate amount of dilute ethanol (50%-60%), after mixingre-usethree-layer tablet pressproceedTableting. _Multifunctional Tablet Press_Catalyst Tablet Press_High Speed Tablet Press_Disinfectant Tablet Press_Tablet Press
(4)Reason:pressed granulesthe physical nature of itself,It is determined by brittleness, plasticity, elasticity and hardness. For example, when elastic substances become smaller under pressure, they will expand due to elasticity after decompression, so the tablets will loosen and crack.
Solution: DifferentParticles,three-layer tablet pressDifferent pressures and other auxiliary materials should be used to control the tableting. _Multifunctional Tablet Press_Catalyst Tablet Press_High Speed Tablet Press_Disinfectant Tablet Press_Tablet Press
(5)Reason:three-layer tablet presstheir own mechanical factors. If the punch length is not uniform, or the pressure adjustment is not appropriate,three-layer tablet pressThe speed is too fast or the particles in the hopper are often less.
Solution: Adjustablethree-layer tablet pressPressure, rotation speed and blanking speed, replace the punch. _Multifunctional Tablet Press_Catalyst Tablet Press_High Speed Tablet Press_Disinfectant Tablet Press_Tablet Press
Key words:
Laboratory Equipment
Packaging Equipment
pharmaceutical equipment
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