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Treatment and maintenance of common problems of tablet press


Chip-packed tablet presses pay attention to maintenance methods. At present, chip-packed tablet presses in many enterprises lack care. Employees are busy with production and neglect the maintenance and maintenance of the machines. Therefore, the usual machine has problems due to a small problem, which leads to the service life of the machine. Attention should be paid to the maintenance and daily care of the chip-packed tablet press. The weight of the tablet is too poor (referring to the difference of the tablet weight exceeding the limit specified in the pharmacopoeia) 1. The particle thickness distribution is uneven, and the particle flow rate is different during tabletting, resulting in uneven particle thickness filled into the middle die hole. For example, if the amount of coarse particles is more, the tablet is light, and if the amount of fine particles is more, the tablet is heavy. Solution: the particles should be mixed or sifted too much fine powder. 2 If fine powder adheres to the punch, the difference in sheet weight can be large during lifting. At this time, the underpunch rotation is not flexible, should be checked in time, remove the die, clean the underpunch and the middle die hole. 3 The fluidity of the particles is not good, and the amount of particles flowing into the middle die hole is more and less, which causes the difference in sheet weight to be too large and exceed the limit. Solution: should be re-granulation or adding suitable glidant such as micro-powder silica gel, improve particle fluidity. 4 particle layering. Solve particle stratification and reduce particle size difference. 5 smaller tablets choose larger particles of material. Solution: Choose the right size particles. 6 hopper is blocked, this phenomenon often occurs in the viscous or hygroscopic strong drug. The hopper shall be dredged, the tableting environment shall be kept dry, and the glidant shall be properly added to solve the problem. 7 There is a large difference in material storage within the material, which is controlled within 50%. 8 The feeder is unbalanced or not installed in place, resulting in uneven packing. 9 The scraping plate is uneven or poorly installed. Solution: leveling. 10 With forced feeder, the speed of the forced feeder wheel does not match the speed of the turntable. Solution: Consistent. 11 The consistency between the punch and the middle die hole is not good, for example, more powder is leaked between the outer periphery of the underpunch and the wall of the die hole, resulting in the phenomenon of "astringent punch" in the underpunch, resulting in insufficient filling of materials. Therefore, the punch and the middle die should be replaced. 12 The length of the undershoot is different and out of tolerance, resulting in uneven filling. Solution: repair the difference, the difference is within ± 5μm. 13 For undershoot with damping, the damping force adjusted by the damping screw is not good. Readjust. 14 The filling track is worn or the filling mechanism is unstable. Solution: Replace or stabilize. 15 The pursuit of output, the turntable speed is too fast, and the filling volume is insufficient. In particular, when pressing large films, the rotation speed should be appropriately reduced to ensure sufficient filling. 16 The tablet press vibrates too much, the structure is loose, the assembly is unreasonable or reassembled; the setting pressure of the tablet press is too large to reduce the pressure.

Key words:

Laboratory Equipment

Packaging Equipment

pharmaceutical equipment

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