There is a dust problem in the tabletting process of the tablet press, which is an urgent problem to be solved. At present, the domestic high-speed rotary tablet press and screen press in the production operation of the dust, the general use of special vacuum cleaner to provide negative pressure to remove its suction. However, due to the gap between the existing technical level and awareness, the sealing effect of the equipment itself is not ideal, and some dust is still discharged to the purification area. In addition, the dust generated by the process of material transportation or tablet transfer may also be directly discharged from the relevant junction to the purification area.

Most small and medium-sized pharmaceutical enterprises in the use of tablet presses still have problems, that is, machine pollution, cleaning difficulties, products can not achieve online testing, equipment operation records by manual filling, etc. Due to the limitations and defects of the equipment, it also brings many practical problems to the GMP management and product quality of the enterprise.

One of the main reasons for the contamination of tablet presses is that the design of the lubrication system is unreasonable, the particularity of pharmaceutical equipment is not fully considered, the equipment lubrication uses a large number of liquid lubricants, and the sealing is not good, which often causes drug contamination. Equipment manufacturers can consider adding grease timing lubrication devices on tablet presses or adopting reliable sealing methods to reduce or eliminate lubricant contamination of drugs. Another major source of pollution is that the sealing between the feeder and the rotating platform is not good, resulting in dust pollution. The British MANESTY adopts a gapless feeder with a polyurethane sealing ring structure to make the bottom of the feeder contact with the middle mold of the turntable to achieve zero clearance, thus avoiding the defects of the current feeder in sealing.

Most domestic tabletting equipment cleaning is very difficult, can not achieve online cleaning. When cleaning, not only should the upper punch, lower punch and middle die be removed, but also there are many dead corners that are not easy to remove and clear. While some foreign tablet presses can achieve rapid loading and unloading and online cleaning. That is, with a small number of tools and adjusting a small number of parts, the parts that need to be cleaned can be quickly and easily assembled and disassembled. Some tablet presses also use a replaceable turntable to achieve rapid cleaning. Domestic tablet presses should also be improved in this regard.

The main development direction of foreign tablet press: production under intelligent and ultra-micro unit control and sealing conditions. Some even use transmission equipment such as magnetic powder clutches and magnetic powder brakes, which shows that foreign tablet presses have taken another step. There are nearly 30 tablet press manufacturers in China, and there are as many as five or six that can produce high-speed tablet presses. However, due to the weakness of basic research, the lack of talents and the imperfect innovation mechanism for a long time, there is still a big gap with foreign advanced tablet press and tablet technology.